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Summary
MM is when plasma cells become malignant and secrete monoclonal proteins1
MM is more common in men, Black individuals, and older individuals (median age of diagnosis is 69 years)2
MM is a clonally heterogenous disease that contributes to treatment resistance and relapse3
High attrition rates underscore the need to use the most optimal treatment regimens upfront rather than reserving them for later LOTs4
With the therapeutic improvement observed in the past few years, achievement of an operational cure is increasingly becoming a realistic goal5
MM, multiple myeloma.
1. American Cancer Society. What is multiple myeloma? Accessed February 20, 2026. https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html. 2. SEER Cancer stat facts: Myeloma. National Cancer Institute. Bethesda, MD. Accessed February 20, 2026. http://seer.cancer.gov/statfacts/html/mulmy.html. 3. Bolli N, et al. Nat Commun. 2014;5:2997. 4. Fonseca R, et al. BMC Cancer. 2020;20(1):1087. 5. Mohty M, et al. Blood. 2021;138(16):1406-1411.
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