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Introduction
Multiple myeloma is a plasma cell neoplasm1
MM is a neoplastic plasma cell disorder characterized by:
- Clonal proliferation of malignant plasma cells in the bone marrow microenvironment secreting monoclonal protein (M-protein) in the blood or urine and causing organ dysfunction including hypercalcemia, renal dysfunction, anemia, and lytic bone lesions1-4
Adapted with permission. © 2014 Terese Winslow LLC, U.S. Govt. has certain rights.
Normal Bone Marrow
MM Bone Marrow
Adapted from Dr. Keats Translational Genomics Research Institute (TGen), Phoenix, AZ.
http://www.keatslab.org/multiple-myeloma-info. Accessed February 10, 2026. In the public domain.
MM, multiple myeloma; M-protein, monoclonal protein.
1. National Cancer Institute. Plasma cell neoplasms (including multiple myeloma) treatment (PDQ®)–patient version. Accessed February 20, 2026. https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq. 2. Kumar SK, et al. Nat Rev Dis Primers. 2017;3:17046. 3. American Cancer Society. What is multiple myeloma? Accessed February 20, 2026. https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html. 4. Manier S, et al. Nat Rev Clin Oncol. 2017;14(2):100-113.
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