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A heterogeneous disease
Evolution of clonal populations of myeloma cells1
- MM undergoes a multistep transformation process and its genetic landscape changes over time due to additional events such as somatic mutations, epigenetic and chromosomal copy-number changes2
- MM is clonally heterogenous starting at diagnosis and throughout treatment. This contributes to treatment resistance and relapse3
Reproduced with permission of American Society of Hematology and HighWire Press.
From Keats JJ et al. Clonal competition with alternating dominance in multiple myeloma. Blood. 2012;20(5):1067-1076; permission conveyed through Copyright Clearance Center, Inc.1
MM, multiple myeloma
1. Keats JJ, et al. Blood. 2012;120(5):1067-1076. 2. Bolli N, et al. Nat Commun. 2014;5:2997. 3. Manier S, et al. Nat Rev Clin Oncol. 2017;14(2):100-113.
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