XARELTO - Transition from or to Apixaban

SUMMARY

• For patients currently receiving an anticoagulant other than warfarin, start XARELTO 0 to 2 hours prior to the next scheduled evening administration of the drug (e.g., low molecular weight heparin or non-warfarin oral anticoagulant) and omit administration of the other anticoagulant. For unfractionated heparin (UFH) being administered by continuous infusion, stop the infusion and start XARELTO at the same time.¹
• For patients currently taking XARELTO and transitioning to an anticoagulant with rapid onset, discontinue XARELTO and give the first dose of the other anticoagulant (oral or parenteral) at the time that the next XARELTO dose would have been taken.¹
• No clinical data is available to guide converting patients from apixaban to XARELTO, or from XARELTO to apixaban.
• Clinicians should use their clinical judgement to weigh benefits vs risks for each patient and refer to product labeling for each product as appropriate.^2-5
• Additional citations are included in the REFERENCES section for your review.^2-9

Literature Search

A literature search of MEDLINE^®, EMBASE^®, BIOSIS Previews^®, and DERWENT^® (and/or other resources, including internal/external databases) pertaining to this topic was conducted on 06 July 2026.