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UPTRAVI® (selexipag)
Patient Medical Information

Can I Crush, Split, or Chew UPTRAVI Tablets?

Last Updated: 06/05/2026

Important information about uptravi

  • Before you take UPTRAVI, tell your healthcare provider if you have narrowing of the pulmonary veins, a condition called pulmonary veno-occlusive disease.1

summary

Here is a passage from the UPTRAVI PATIENT INFORMATION which may be helpful to address your question:

Can I crush, split, or chew UPTRAVI tablets?

  • Swallow UPTRAVI tablets whole. Do not split or crush UPTRAVI tablets.1
  • If you or your child cannot swallow the tablets1:
    • Dissolve (disperse) the 100 mcg or 150 mcg tablet(s) in apple or orange juice. Do not disperse the tablet(s) in water or milk.
      • Place the required number of tablet(s) for the prescribed dose in a cup. Do not crush or split the tablet(s).
      • Add 1 or 2 teaspoons of apple or orange juice to the prescribed number of tablets.
      • Wait for 5 minutes, then stir the juice and the tablet(s) until the tablets are dispersed.
      • Take or give the mixture right away.
    • UPTRAVI tablets can also be given with soft foods as follows:
      • Cover the prescribed number of 100 mcg or 150 mcg tablets with a small amount of soft food, such as yogurt, applesauce or mashed bananas.
      • Take or give the mixture right away. Make sure no remaining medicine is left in the container by adding more soft food and take or give the mixture right away.

Do not store UPTRAVI tablets that are already mixed with juice or soft food for later use.1

additional information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response. 

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for UPTRAVI.1

 

References

1 UPTRAVI (selexipag) [Prescribing Information]. Titusville, NJ: Actelion Pharmaceuticals US, Inc, a Janssen Pharmaceutical Company: Actelion Pharmaceuticals US, Inc; https://www.jnjlabels.com/package-insert/product-monograph/prescribing-information/UPTRAVI-pi.pdf
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