Dosing - Splitting TOPAMAX Tablets

SUMMARY

• TOPAMAX tablets are not scored; therefore, they are not intended to be split.
• Splitting unscored TOPAMAX tablets is not recommended due to the inability to assure the intended dosage in each fragment.
• Dose variation could lead to adverse clinical outcomes.
• Evaluations have not been performed to assure drug stability, safety or efficacy when using broken, divided or otherwise altered TOPAMAX tablets.
• If the tablets are broken, their stability cannot be guaranteed for any period of time.
• TOPAMAX is a white crystalline powder with a bitter taste.¹
• Once the integrity of the film coating is compromised, the bitter taste may no longer be masked.
• In summary, clinical consequences should be considered due to stability, dose variation, and patient compliance.

Literature Search

A literature search of MEDLINE^®, Embase^®, BIOSIS Previews^®, and Derwent Drug File (and/or other resources, including internal/external databases) pertaining to this topic conducted on 01 July 2026 did not identify relevant citations pertaining to splitting TOPAMAX tablets.