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Here is a passage from the RYBREVANT FASPRO PATIENT INFORMATION which may be helpful to address your question:

What are the possible side effects of RYBREVANT FASPRO?

RYBREVANT FASPRO may cause serious side effects, including:

• allergic and injection-related reactions. Allergic and injection-related reactions are common and can be severe or serious. Tell your healthcare provider right away if you get any of the following symptoms during or after your injection of RYBREVANT FASPRO¹:
  • shortness of breath
  • fever
  • chills
  • flushing
  • chest discomfort
  • dizziness or lightheadedness
  • vomiting
• lung problems. RYBREVANT FASPRO can cause lung problems that can lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you get any new or worsening lung symptoms, including¹:
  • shortness of breath
  • cough
  • fever
• blood clot problems. RYBREVANT FASPRO, when given in combination with lazertinib, can cause blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) that can lead to death. Your healthcare provider may start you on medicine to prevent blood clots for the first 4 months of treatment. Tell your healthcare provider right away if you get any signs and symptoms of blood clots, including¹:
  • swelling, pain or tenderness in the leg
  • sudden unexplained chest pain
  • shortness of breath
• skin problems. RYBREVANT FASPRO can cause severe rash; including blisters, peeling, skin pain and sores, redness, raised acne-like bumps, itching, and dry skin. Your healthcare provider may start you on an antibiotic for the first 3 months of treatment followed by an antibiotic lotion for your scalp for the next 9 months. During treatment with RYBREVANT FASPRO, you should apply a non-comedogenic (does not clog pores) skin moisturizer (ceramide-based or other types of moisturizers that provide long-lasting skin hydration and does not include drying ingredients) on your face and whole body (except scalp) and wash your hands and feet every day with 4% chlorhexidine solution. Tell your healthcare provider right away if you get any skin reactions. Your healthcare provider may treat you with a medicine(s) or send you to see a skin specialist (dermatologist) if you get skin reactions during treatment with RYBREVANT FASPRO.¹
  • RYBREVANT FASPRO can cause skin reactions. You should limit your time in the sun during and for 2 months after your treatment with RYBREVANT FASPRO. Wear protective clothing and use broad-spectrum sunscreen during treatment with RYBREVANT FASPRO.
• eye problems. RYBREVANT FASPRO can cause eye problems. Tell your healthcare provider right away if you get symptoms of eye problems which may include¹:  
  • eye pain
  • changes in vision
  • inflammation of eyelids
  • dry eyes
  • eye redness
  • blurred vision
  • itchy eyes
  • excessive tearing
  • sensitivity to light

Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get new or worsening eye problems during treatment with RYBREVANT FASPRO. You should not use contact lenses until your eye symptoms are checked by a healthcare provider.¹

The most common side effects of RYBREVANT FASPRO in combination with lazertinib include¹:

• rash
• infected skin around the nail
• muscle and joint pain
• feeling very tired
• sores in the mouth
• swelling of hands, ankles, feet, face, or all of your body
• nausea
• diarrhea
• vomiting
• constipation
• decreased appetite
• headache
• changes in certain blood tests

The most common side effects observed with intravenous (IV) amivantamab, which may be experienced with RYBREVANT FASPRO are listed below:

• The most common side effects of IV amivantamab in combination with lazertinib include¹:
  • rash
  • infected skin around the nail
  • infusion-related reactions
  • muscle and joint pain
  • sores in the mouth
  • swelling of hands, ankles, feet, face or all of your body
  • unusual feeling in the skin (such as tingling or a crawling feeling)
  • feeling very tired
  • diarrhea
  • constipation
  • COVID-19
  • bleeding
  • dry skin
  • decreased appetite
  • itching
  • nausea
  • changes in certain blood tests
• The most common side effects of IV amivantamab in combination with carboplatin and pemetrexed include¹:
  • rash
  • infected skin around the nail
  • infusion-related reactions
  • feeling very tired
  • nausea
  • sores in the mouth
  • constipation
  • swelling of hands, ankles, feet, face, or all of your body
  • decreased appetite
  • muscle and joint pain
  • vomiting
  • COVID-19
  • changes in certain blood tests
• The most common side effects of IV amivantamab when given alone include¹:
  • rash
  • infusion-related reactions
  • infected skin around the nail
  • muscle and joint pain
  • shortness of breath
  • nausea
  • cough
  • feeling very tired
  • sores in the mouth
  • constipation
  • vomiting
  • changes in certain blood tests
  • swelling of hands, ankles, feet, face, or all of your body

Your healthcare provider may temporarily stop, decrease your dose or completely stop your treatment with RYBREVANT FASPRO if you have serious side effects.¹

These are not all of the possible side effects of RYBREVANT FASPRO.¹

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.¹

ADDITIONAL INFORMATION

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for RYBREVANT FASPRO.¹