summary

Here is a passage from the INVEGA TRINZA PRESCRIBING INFORMATION which may be helpful to address your question:

How long does it take INVEGA TRINZA to leave my body?

• Due to its extremely low water solubility, the 3-month formulation of paliperidone
• palmitate dissolves slowly after intramuscular ("into the muscle") injection before being hydrolyzed (“broken down”) to paliperidone and absorbed into the systemic circulation.¹
• After receiving an injection of INVEGA TRINZA, the release of the drug starts as early as day 1 and lasts as long as 18 months.¹
• The median (“middle”) apparent half-life (“time to reduce amount by half”) of paliperidone following administration over the dose range of 273-819 mg ranged from 84-95 days following deltoid (“arm”) injections and 118-139 days following gluteal (“buttock”) injections.¹

additional information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest use in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for INVEGA TRINZA.¹