J&J Medical Connect
INVEGA HAFYERA®

(paliperidone palmitate 6-month)

This information is intended for US patients and caregivers to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended to promote the use of our products, nor to provide medical advice.

How Long Does It Take INVEGA HAFYERA to Leave My Body?

Last Updated: 06/13/2025

summary

Here is a passage from the INVEGA HAFYERA PRESCRIBING INFORMATION which may be helpful in addressing your question:

How long does it take INVEGA HAFYERA to leave my body?

  • When INVEGA HAFYERA is injected into a muscle, it dissolves slowly. It is broken
  • down into paliperidone palmitate, the active ingredient in INVEGA HAFYERA, and absorbed into the bloodstream.1
  • After receiving an injection of INVEGA HAFYERA, the release of the drug starts as early as day 1 and is predicted to last longer than 18 months.1
  • The median ("middle") apparent half-life of paliperidone palmitate, the active ingredient in INVEGA HAFYERA, following a single dose of either 1,092 mg or 1,560 mg was 148 and 159 days respectively.1

additional information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest use in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and PATIENT INFORMATION for INVEGA HAFYERA.1

References

1 INVEGA HAFYERA (paliperidone palmitate) extended-release injectable suspension [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+HAFYERA-pi.pdf