SUMMARY  

• Johnson and Johnson cannot recommend any practices, procedures, or dosing modifications that deviate from product labeling and are not approved by the regulatory agencies.
• Studies have only been performed on whole capsules with respect to in vitro/in vivo release profiles, absorption, and pharmacokinetics.
• The effect of chewing, crushing, or splitting CAPLYTA capsules on stability is unknown.

Literature Search

A literature search of MEDLINE^®, EMBASE^®, BIOSIS Previews^®, and DERWENT^® (and/or other resources, including internal/external databases) conducted on 13 October 2025 did not identify any relevant citations pertaining to this topic.