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CAPLYTA®

(lumateperone)

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This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.

CAPLYTA® (lumateperone)
Medical Information

CAPLYTA – Capsule Crushing, Chewing, or Splitting

Last Updated: 03/18/2026

SUMMARY  

  • Johnson and Johnson cannot recommend any practices, procedures, or dosing modifications that deviate from product labeling and are not approved by the regulatory agencies.
  • Studies have only been performed on whole capsules with respect to in vitro/in vivo release profiles, absorption, and pharmacokinetics.
  • The effect of chewing, crushing, or splitting CAPLYTA capsules on stability is unknown.

Literature Search

A literature search of MEDLINE®, EMBASE®, BIOSIS Previews®, and DERWENT® (and/or other resources, including internal/external databases) conducted on 13 October 2025 did not identify any relevant citations pertaining to this topic.

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