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XARELTO®

(rivaroxaban)

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XARELTO - Management of Bleeding - EINSTEIN - Treatment of DVT and PE

Last updated : 05/16/2024

Eerenberg et al (2015) conducted a post hoc analysis to compare the severity of clinical presentation and clinical course for major bleeding with XARELTO vs LMWH/VKA in patients involved in the EINSTEIN studies.1

Efficacy Outcomes1
(N=8246)

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Outcomes

XARELTO

LMWH/VKA

Major bleeding episodes, n

40

68

Number of times FFP was administered, n

3

9

Number of times PCC was administered, n

2

8

Number of times rFVIIa was administered, n

1

-

Erythrocyte transfusion for bleeds, %

35

65

  • In the analysis, vitamin K was given 28 times, but only once to a patient being treated with XARELTO.1

DVT, deep vein thrombosis; FFP, fresh frozen plasma; LMWH, low-molecular weight heparin; PCC, prothrombin complex concentrate; PE, pulmonary embolism; rFVIIa, recombinant factor VIIa; VKA, vitamin K antagonist.

LMWH, low-molecular weight heparin; VKA, vitamin K antagonist.

Reference

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1. Eerenberg ES, Middeldorp S, Levi M, et al. Clinical impact and course of major bleeding with rivaroxaban and vitamin K antagonists. J Thromb Haemost. 2015;13(9):1590-1596.