J&J Medical Connect
TREMFYA®

(guselkumab)

This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.

TREMFYA® Prefilled Pen 200 mg/2 mL – Preparation

Change dosage

Last updated: 08/10/2026

You will need:

One or two 200 mg Prefilled Pen(s) based on the dose prescribed by your Healthcare Provider

Not provided in the carton:

Alcohol swabs

Adhesive bandages

Cotton balls or gauze pads

Sharps container

STEP 1: Get ready

Check your prescribed dose to see if you will need to use 1 or 2 TREMFYA PEN(s).

STEP 2: Inspect carton

Remove the carton(s) from the refrigerator.

Check the expiration (EXP) date.

Do not use TREMFYA PEN(s) if the expiration date has passed or if the seal on the carton is broken.

Contact your healthcare provider or pharmacist for a new TREMFYA PEN.

Allow TREMFYA PEN(s) to come to room temperature.

Let the carton(s) sit on a surface at room temperature for approximately 30 minutes before use.

Do not warm the TREMFYA PEN(s) any other way.

STEP 3: Inspect TREMFYA PEN

Check the liquid in the viewing window.

It should be clear and colorless to slightly yellow and may contain tiny white or clear particles. You may also see air bubbles. This is normal.

Do not inject if the liquid:

  • is cloudy
  • is discolored
  • has large particles

Contact your healthcare provider or pharmacist for a new TREMFYA PEN.

STEP 4: Choose injection site

Select from the following areas for injection:

  • Front of thighs
  • Lower stomach area (lower abdomen), except for a 2-inch area right around your navel (belly button)
  • Back of upper arms (only if someone else is giving you the injection)

If you need to give 2 injections to complete your dose, choose different areas or leave at least 2 inches between injection sites.

Do not inject into skin that is tender, bruised, red, scaly, thick, or hard.

Avoid areas with scars or stretch marks.

STEP 5: Wash hands and clean injection site

Wash your hands well with soap and warm water.

Wipe your chosen injection site with an alcohol swab and allow it to dry.

Do not touch, fan, or blow on the injection site after you have cleaned it.

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