SUMMARY

• Here is a passage from the MEDICATION GUIDE which may be helpful to address your question.
• SPRAVATO Risk Evaluation and Mitigation Strategy (REMS): Because of the risks for sedation, dissociation, respiratory depression, abuse and misuse, SPRAVATO is only available through a restricted program called the SPRAVATO Risk Evaluation and Mitigation Strategy Program. SPRAVATO can only be administered at healthcare settings certified in the SPRAVATO REMS Program. Patients treated in outpatient healthcare settings (such as medical offices and clinics) must be enrolled in the program.1

HOW WILL I TAKE SPRAVATO?1

• You will take SPRAVATO nasal spray yourself, under the direction and supervision of a healthcare provider in a REMS certified healthcare setting. Your healthcare provider will show you how to use the SPRAVATO nasal spray device.1
• Your healthcare provider must monitor you for serious side effects for at least 2 hours after taking SPRAVATO. Your healthcare provider will decide when you are ready to leave the healthcare setting.1
• Your healthcare provider will tell you how much SPRAVATO you will take and when you will take it.1
• Follow your SPRAVATO treatment schedule exactly as your healthcare provider tells you to.
• The recommended dose of SPRAVATO in adults with treatment-resistant depression (TRD) with or without an antidepressant taken by mouth, and for major depressive disorder (MDD) with acute suicidal thoughts or actions along with an antidepressant taken by mouth is shown in Figure: Recommended Dosage for SPRAVATO Nasal Spray in Adults with TRD and MDD with Acute Suicidal Ideations or Behavior.1
• During and after each use of the SPRAVATO nasal spray device, you will be checked by a healthcare provider, who will decide (after at least two hours of monitoring) when you are ready to leave the healthcare setting.1
• You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO.1
• If you miss a SPRAVATO treatment, your healthcare provider may change your dose and treatment schedule.1
• Some people taking SPRAVATO get nausea and vomiting. You should not eat for at least 2 hours before taking SPRAVATO and not drink liquids at least 30 minutes before taking SPRAVATO.1
• If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least 1 hour before taking SPRAVATO.1

Recommended Dosage for SPRAVATO Nasal Spray in Adults with TRD and MDD with Acute Suicidal Ideation or Behavior1

Abbreviations: MDD, major depressive disorder; TRD, treatment-resistant depression. Each intranasal device delivers two sprays containing a total of 28 mg of esketamine.

ADDITIONAL INFORMATION

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest use in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the MEDICATION GUIDE for SPRAVATO.1

REFERENCES