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RYBREVANT FASPRO™

(amivantamab and hyaluronidase-lpuj)

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This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.

RYBREVANT FASPRO™ (amivantamab and hyaluronidase-lpuj)

Medical Information

RYBREVANT FASPRO - Vial Overfill

Last Updated: 12/17/2025

SUMMARY

  • RYBREVANT FASPRO (amivantamab and hyaluronidase-lpuj) for subcutaneous (SC) administration is a coformulation of amivantamab with recombinant human hyaluronidase PH20 (rHuPH20).1
  • Each RYBREVANT FASPRO 10 mL single-dose (preservative-free) vial contains 1600 mg of amivantamab and 20,000 units of hyaluronidase (160 mg and 2000 units/mL) solution with an overfill volume of 1.2 mL (for the current commercial manufacturing site).2,3
  • Each RYBREVANT FASPRO 14 mL single-dose (preservative-free) vial contains 2240 mg of amivantamab and 28,000 units of hyaluronidase (160 mg and 2000 units/mL) solution with an overfill volume of 1.3 mL (for the current commercial manufacturing site).2,3
  • Discard unused portion.3
  • Please refer to the DOSAGE AND ADMINISTRATION and HOW SUPPLIED/STORAGE AND HANDLING sections of the full Prescribing Information for RYBREVANT FASPRO for complete information.3

LITERATURE SEARCH

A literature search of MEDLINE®, Embase®, BIOSIS Previews®, and Derwent Drug File (and/or other resources, including internal/external databases) was conducted on 09 December 2025.

References

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1 Leighl NB, Akamatsu H, Lim SM, et al. Subcutaneous versus intravenous amivantamab, both in combination with lazertinib, in refractory epidermal growth factor receptor-mutated non-small cell lung cancer: primary results from the phase III PALOMA-3 study. J Clin Oncol. 2024;42(30):3593-3605.  
2 Data on File. Technical Document Overfill Verification Report for Amivantamab (JNJ-61186372, CNTO 4424) 1600 mg and 2240 mg FVP. Janssen Research & Development, LLC. TV-TEC-249411; 2022.  
3 RYBREVANT FASPRO (amivantamab and hyaluronidase-lpuj) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RYBREVANT+Faspro-pi.pdf