LAZCLUZE®
(lazertinib)
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This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.
LAZCLUZE® (lazertinib)
Medical Information
RYBREVANT - Specialty Distributors
Last Updated: 08/26/2025
BACKGROUND
- RYBREVANT (amivantamab-vmjw) is indicated in combination with LAZCLUZE (lazertinib) for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) Exon 19 deletions or Exon 21 L858R substitution mutations, as detected by a Food and Drug Administration (FDA)-approved test.1
- RYBREVANT is indicated in combination with carboplatin and pemetrexed for the treatment of adult patients with locally advanced or metastatic NSCLC with EGFR Exon 19 deletions or Exon 21 L858R substitution mutations, whose disease has progressed on or after treatment with an EGFR tyrosine kinase inhibitor.1
- RYBREVANT is indicated in combination with carboplatin and pemetrexed for the first-line treatment of adult patients with locally advanced or metastatic NSCLC with EGFR Exon 20 insertion mutations, as detected by an FDA-approved test.1
- RYBREVANT is indicated as a single agent for the treatment of adult patients with locally advanced or metastatic NSCLC with EGFR Exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy.1
PRODUCT LABELING
- RYBREVANT (amivantamab-vmjw) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RYBREVANT-pi.pdf.
- LAZCLUZE (lazertinib) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/LAZCLUZE-pi.pdf.
ACCESSING RYBREVANT THROUGH SPECIALTY DISTRIBUTORS
- The Specialty Distributors authorized to sell RYBREVANT can be found in Table: Specialty Authorized Distributors for RYBREVANT.
| Name | Phone Number | Fax | Website | Drug Fulfillment |
|---|---|---|---|---|
| McKesson Specialty Health | Oncology: 800-482-6700 Multispecialty: 855-477-9800 | Oncology: 855-824-9489 Multispecialty: 800-800-5673 | mckessonspecialtyhealth.com | RYBREVANT® |
| McKesson Plasma and Biologic | 877-625-2566 | 888-752-7626 | connect.mckesson.com | RYBREVANT® in combination with LAZCLUZE® |
| Cencora (AmerisourceBergen) | 800-746-6273 | 800-547-9413 | asdhealthcare.com | RYBREVANT® in combination with LAZCLUZE® |
| Cencora Oncology Supply (AmerisourceBergen Oncology Supply) | 800-633-7555 | 800-248-8205 | oncologysupply.com | RYBREVANT® in combination with LAZCLUZE® |
| Cardinal Health Specialty Pharmaceutical Distribution | Physician offices: 877-453-3972 Hospitals/All others: 855-855-0708 | 614-652-7043 | specialtyonline.cardinalhealth.com orderexpress.cardinalhealth.com | RYBREVANT® in combination with LAZCLUZE® |
| Cardinal P.R. 120 (Puerto Rico) | 787-625-4200 | 787-625-4398 | cardinalhealth.pr | RYBREVANT® in combination with LAZCLUZE® |
| CuraScript SD (Priority Healthcare) | 877-599-7748 | 800-862-6208 | curascriptsd.com | RYBREVANT® in combination with LAZCLUZE® |
| Morris & Dickson Specialty Distribution | 1-800-710-6100 | 318-524-3096 | morrisdickson.com mdspecialtydist.com | RYBREVANT® in combination with LAZCLUZE® |
| BioCare Specialty Distribution | 1-800-304-3064 | biocare-us.com | RYBREVANT® in combination with LAZCLUZE® |
References
| 1 | RYBREVANT (amivantamab-vmjw) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RYBREVANT-pi.pdf |
| 2 |