SUMMARY  

• Use with non-Janssen COVID-19 Vaccines
  • Currently, there are no published studies on the concomitant use of other manufacturers’ COVID-19 vaccines and CARVYKTI.
  • Clinicians should use clinical judgement based on local/institutional guidelines, standards of care, and individual patient risk/benefit assessment when considering concomitant use of CARVYKTI and the non-Janssen COVID-19 vaccine.
  • For additional information regarding the use of non-Janssen COVID-19 vaccines, please refer to the vaccine manufacturer.
• General Vaccination Information
  • Refer to the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices COVID-19 Vaccine Recommendations and General Best Practice Guidelines for Altered Immunocompetence.^1,2
  • Country-specific health authority and medical society recommendations may be available regarding the use of COVID-19 vaccines in oncology patients, including information regarding additional mRNA COVID-19 vaccine dose recommendations for patients with hematologic malignancies receiving active treatment. Relevant content from the most-recognized organizations is listed below. However, this list is not a complete list of publicly available resources. The content is subject to change as evidence evolves.
    • For information from the World Health Organization, visit: COVID-19 Vaccines
    • For information from the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices, visit: ACIP Recommendations: COVID-19 Vaccine, General Best Practice Guidelines for Altered Immunocompetence, and Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Authorized in the United States
    • For information from the American Society for Hematology, visit: COVID-19 Resources
    • For information from the British Society for Haematology, visit: COVID-19 Updates
    • For information from the European Hematology Association, visit: EHA Statement on COVID-19 Vaccines
    • For information from the European Society for Blood and Marrow Transplantation, visit: COVID-19 and BMT
    • For information from the National Comprehensive Cancer Network, visit:
      Management of Concurrent COVID-19 and Cancer in Patients
    • For information from the International Myeloma Society, visit: Recommendations for the Management of Myeloma Patients During the COVID-19 Pandemic

Literature Search

A literature search of MEDLINE^®, Embase^®, BIOSIS Previews^®, and Derwent Drug File databases (and/or other resources, including internal/external databases) was conducted on 11 November 2024.